PDPN and cancer: Although the mechanisms controlling this upregulation are completely unknown, podoplanin expression can be modulated by a number of factors, including those with the potential to induce invadopodia formation/function such as EGF and TGFβ.18, 23, 40, 41 Our present study suggests that podoplanin mediates ECM remodelling in all these contexts by controlling the stability of invadopodia in keratinocytes, pointing to a direct role for this glycoprotein in cancer cell adhesion and invasion.