Since we observed that P2X7 as well as PI3K/AKT and ERK1/2 signaling pathways exhibited important effects on ATP- and BzATP-driven migration, invasion and expression changes of EMT/invasion-related genes in prostate cancer cells, we wondered whether P2X7 was involved in ATP- and BzATP-induced activation of PI3K/AKT and ERK1/2 signaling pathways. The gene discussed is MAPK3; the disease is prostate cancer.