For example, low expression levels of miR-34a, one of the predicted direct targets of p53, are associated with poor outcome in breast cancer (p-value = 0.0009), while high expression levels are associated with a poor outcome in ovarian carcinoma and hepatocellular carcinoma (p-values = 0.049) (Fig. S4). This evidence concerns the gene TP53 and hepatocellular carcinoma.