On the other hand, the discovery of mutations associated with familial forms of PD including α-synuclein, Parkin, DJ-1, ubiquitin C-terminal hydrolase L1 T (UCHL1), PTEN-induced putative kinase 1 (Pink1), and Leucine-rich repeat kinase (LRRK2) has led to the generation of genetic mouse models of Parkinsonism (for review see [18]). This evidence concerns the gene PINK1 and Parkinson disease.