NME2 and Alzheimer disease: Besides, nm23 nucleoside diphosphate kinase/metastatic inhibitory protein (PuF), encoded by nm34-H2 gene, may regulate the promoter of Aβ precursor protein gene (a gene that account for a part of familial AD) and that AD risk may be increased by interference with PuF regulation at the proximal regulatory element (PRE) [16].