NME8 and Alzheimer disease: In our analysis of 93 regions of interest regional volume via MRI in whole group and subgroups, NME8 gene rs2718058 was significantly associated with baseline right middle occipital gyrus (P = 0.002), right inferior occipital gyrus (P = 0.021) and left middle occipital gyrus (P = 0.010) in the AD subgroup by the ANOVA analysis (Fig. 2).