Sainath and Reddy [12] observed an increase of phosphorylase activity in hepatopancreas and muscle of intact and eyestalkless crab Oziotelphusa senex senex when injected with melatonin (10−7 mol·crab−1), and also hyperglycemia in a dose-dependent manner (10−10–10−5 mol·crab−1), which supports the hypothesis that melatonin-induced hyperglycemia is not through CHH from the eyestalk, at least in this species. The gene discussed is RMRP; the disease is Hyperglycemia.