Fig. 3C shows that no NF-kB or RAM-11 staining was detected in the aorta of the normal rabbits, whereas the HFC diet resulted in strong RAM-11 and NF-kB staining in the intima in the control group. Both effects were significantly reduced by vaccination with Fc-CETP6 (Fig. 3D). In summary, our results show that immunization with Fc-CETP6 reduced the extent of aortic inflammation and macrophage infiltration, and thus decreased susceptibility to atherosclerosis progression in the rabbit aorta. This evidence concerns the gene NFKB1 and atherosclerosis.