HIF1A and adrenocortical carcinoma, hereditary: To determine the biological effect and the relationship between survivin, HIF-1α, TGF-β1 and TFE3 in NSG, PA and AdCC, we evaluated the correlation of expression of survivin with the immunohistochemical protein expression of HIF-1α, TGF-β1 and TFE3 using the Aperio Scan Scope, a rather objective computer-based scanning and quantification technology.