It is interesting to note that the high expression of TFE3 in AdCC is not only related with high expression of TGF-β1 (P<0.0001, r = 0.6502) but also correlated with HIF-1α (P<0.001, r = 0.5216) as shown in Fig. 7B. The gene discussed is HIF1A; the disease is adrenocortical carcinoma, hereditary.