More importantly, TGF-β1 and TFE3 significantly increase in AdCC but not in MEC suggest the potential role of TGF-β1/TFE3 axis in AdCC progression, which may related to AdCC's unique biological behavior on EMT[47], distant metastasis and angiogenesis[48] as compared with MEC. Here, TGFB1 is linked to adrenocortical carcinoma, hereditary.