Interestingly, the cell cycle regulating genes associated with tumor growth such as cyclin D1 and USP44 are regulated by KLF8 in T80 [4] but not in MCF10A, whereas the EMT and metastasis associated genes such as E-cadherin, MMPs, and EPSTI1 are regulated by KLF8 in MCF10A [3, 7, 8] but not in T80 [4]. The gene discussed is KLF8; the disease is neoplasm.