Comprehensive analysis of the early stage network for proteins that are supported by the number of literature-derived evidence revealed that five candidates (LRP8, GRM1, CTSB, GRK5, LDLR) are highly speculated as biomarkers in the literature in terms of their novelty in the context of core AD pathomechanism so that they are altogether supported by 17 speculative statements. This evidence concerns the gene CTSB and Alzheimer disease.