The trend is not as clear for demethylase, but we note that KDM5B, which removes the activating mark H3K4me3, is significantly overexpressed in five of the eight cancer types studied and never repressed, while the H3K27me3 demethylases KDM6A/B are repressed in most cancer types (Figure 6C). The gene discussed is KDM6A; the disease is cancer.