Among our 441 chromatin factors, the most frequently amplified/overexpressed genes were ACTL6A, a component of the SWI/SNF chromatin remodeling complex that is overexpressed and amplified in 53% of lung squamous cell carcinoma samples, and FXR1, a gene that codes for a Tudor domain containing protein that is also overexpressed and amplified in 53% of the same tumor type. The gene discussed is FXR1; the disease is squamous cell lung carcinoma.