In contrast, two of the best powered European studies which have analyzed the effect of these FTO variants on obesity are by Thomsen et al. [14] and Frayling et al. [10] who observed odds ratios of 1.42 (95% CI: 1.33–1.52) and 1.32 (95% CI: 1.26–1.39), respectively. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.