Moreover, Poloxin targets Plk1 in a panel of cancer cell lines with a high specificity by showing prometaphase arrest, delocalization of Plk1 itself, reduction of γ-tubulin recruitment to centrosomes, defects in the mitotic spindle formation, activation of the spindle assembly checkpoint and induction of apoptosis, and it inhibits tumor growth in vivo [18-20]. This evidence concerns the gene PLK1 and cancer.