We also noticed the luminal epithelial cell tumor gradually reduced yet CD44+ and CK5+/CK8+ stem-like tumor gradually increased from the 16wks (Fig. 2d), suggesting that while 16-20 wks tumor volume became smaller with decreased epithelial markers than those of 12 wks before ADT-castration, they did have increased stem-like cell markers with more metastatic foci formation (Supplemental Fig. 1). This evidence concerns the gene KRT5 and neoplasm.