LEP and neoplasm: Analysis of angiogenic markers from all three compartments (tumor cells, stroma cells, and serum) revealed high serum expression for five angiogenic cytokines and five MMPs as compared to tumor and stroma tissue (p < 0.001; Figure 1): angiopoietin-2, follistatin (tumor only), CSF, leptin, PDGF-BB, MMP-1,-2,-7,-9 and -10.