Of note, increased circulating PA28γ were only detected in 10.7% (3/28) of patients with different types of cancer (Figure 2A).The frequency of different human PA28γ serum levels is displayed in Figure 2B. Most sera showed a PA28γ levels between 10 and 40 ng/ml and were therefore below the calculated cutoff. This evidence concerns the gene PSME3 and cancer.