ANXA1 and laminopathy: For example loss of function of FLNA has been associated with a wide spectrum of connective tissue and vascular abnormalities [49], glucocorticoid-induced ANXA1 induction has been recently related with immune-mediated inflammation and the pathogenesis of reumathoid artritis [50], laminA recently has been correlated with immune cell functions [51], while both A and B type lamin mutations and/or defects in their expression or post-translational processing, cause a heterogeneous group of diseases known as laminopathies [52].