AR and cancer: An unanticipated role of cytoskeletal proteins such as FLNA in the nucleus has also been suggested by the findings that FLNA interacts with androgen receptor (AR) and suppresses AR transcriptional activity [20] and by a recent report showing that FLNA plays a role in the repair of a variety types of DNA damage and that lack of FLNA increases cell sensitivity to DNA damage-based cancer therapy [21].