By univariate analysis, RFPL3 upregulation (P < 0.001), T3 stage (P = 0.008) and presence of lymph node metastasis (P < 0.001) were significant inferior prognostic factors for OS in patients with lung adenocarcinoma (Table 1B). The gene discussed is RFPL3; the disease is metastatic malignant neoplasm in the lymph nodes.