Hexokinase type IV, more typically called Glucokinase (GK), is a glucose-phosphorylating enzyme that has been shown to be the key molecule for glucose sensing in mammalian liver and pancreas cells[46] and mutations in GK are known to cause Maturity Onset Diabetes of the Young Type II (MODY2)[47, 48]. The gene discussed is GCK; the disease is maturity-onset diabetes of the young type 2.