Despite the fact that the exact function of podoplanin in odontogenic tumors is poorly understood and largely unknown, the results of the present study taken together with our previous investigation [9] and those of others authors [5, 17, 8, 10] strongly suggest that this protein is involved in local invasion and in the expansive growth of keratocystic odontogenic tumors, probably orchestrating the odontogenic epithelial cytoskeleton activity. This evidence concerns the gene PDPN and odontogenic neoplasm.