NKX3-2 and familial isolated congenital asplenia: Although the pleiotropic role of Bapx1 was known and many phenotypes defined, our approach is the first large-scale effort looking at all the major tissues expressing Bapx1. This allowed us to make connections between many new genes previously unknown to be controlled by Bapx1. The large scale dataset generated enabled us to place these genes within pathways they control, essentially explaining the lack of a limb phenotype, the absence of an overt morphological phenotype in the gut and the impact on cell cycle regulation in the spleen leading to asplenia in the Bapx1 loss-of-function mice.