RYR2 and catecholaminergic polymorphic ventricular tachycardia: This heterogeneity of RyR2 dysfunction caused by CPVT mutations is actually expected if we consider that most CPVT mutations fall in domains of the RyR2 sequence that control several aspects of channel function, including regions involved in Ca2+ sensing, excitation-contraction coupling, phosphorylation, redox sensing, and others (reviewed in [30]).