COPD patients exhibit elevated levels of inflammatory biomarkers including CRP, TNF-α, fibrinogen, leukocytes, IL-6, and IL-8 [34, 35] suggesting that COPD may be similar to other diseases associated with systemic inflammation including CAD, peripheral arterial disease, osteoporosis and diabetes [14]. Here, CXCL8 is linked to chronic obstructive pulmonary disease.