In addition, we observed favorable dose–response relations across subgroups of exercise adherence (minutes/week) with respect to 12-month changes in body weight, total body fat, and intra-abdominal fat area[20], circulating free estradiol and sex hormone-binding globulin (SHBG) levels[19], insulin and the homeostasis model assessment of insulin resistance (HOMA-IR), leptin, adiponectin:leptin[21] and high sensitivity C-reactive protein (CRP), with the strongest changes occurring when exercise exceeded 150 or 225 minutes/week. The gene discussed is LEP; the disease is Insulin resistance.