Moreover, it was reported that tumor cell invasion is activated by MMP2, which is a 72 kDa type IV collagenase involved in the breakdown of extracellular matrix to help cell invasion [23], and AKT signaling pathway activates MMP2 and enhances cell invasion in different cancers, such as breast cancer and lung cancer [24, 25]. Here, AKT1 is linked to breast carcinoma.