It is also a potent oncogene, and deregulation of MYC expression due to genetic lesions (e.g., translocations, amplifications, and mutations) or other mechanisms is one of the more common alterations in cancer, having been implicated in the pathogenesis of many types of human neoplasms including a variety of solid tumors and lymphoid malignancies [5]. The gene discussed is MYC; the disease is cancer.