Similarly, Ad36 improves hyperglycemia and hepatic steatosis in high-fat diet mice, and there is also evidence of reduced hyperglycemia and lower lipid concentrations in the livers of Ad36-seropositive humans [23] It has been proposed that Ad36 infection increases glucose uptake in adipocytes by activating the Ras and Akt signaling pathways, thereby leading to increased translocation of Glut4 (glucose transporter 4) [7], [8], [25]. The gene discussed is AKT1; the disease is Hyperglycemia.