TJP1 and metabolic dysfunction-associated steatotic liver disease: Miele et al. [13] demonstrated a high prevalence of SIBO, increased intestinal permeability (urinary excretion of 51Cr-ethylene diamine tetraacetate (51Cr-EDTA) test), and disruption of the intercellular tight junctions of the gut (immunohistochemical analysis of zona occludens-1 (ZO-1) expression in duodenal biopsy specimens) in NAFLD patients.