Interestingly, although we could not quantify NFKB1 gene expression in SK-MEL-28 cells via qPCR (Fig. 1D), the two tumor cell lines treated with Amblyomin-X showed a block in the proteolysis of the NFKB1 subunit p105 after 24 h of treatment (Fig. 2C). The gene discussed is NFKB1; the disease is neoplasm.