Klimiuk et al. reported that patients with early RA showed high serum concentrations of soluble ICAM-1 and E-selectin levels [43], and the same group also showed that the serum concentrations of soluble ICAM-1 levels correlated with markers of disease activity, such as the erythrocyte sedimentation rate (ESR) and CRP levels [44]. The gene discussed is CRP; the disease is rheumatoid arthritis.