Fibroblast-like synoviocytes in RA patients secrete a number of cytokines, chemokines and matrix-degrading enzymes, including IL-1α, IL-1β, IL-6, IL-8 and MMPs, which may create an inflammatory environment in the synovium and contribute to progressive joint destruction [68,69,70]. Here, CXCL8 is linked to rheumatoid arthritis.