Double staining with Ki67 and α-SMA antibodies showed most nuclear ki67-positive vessel cells coexpressed α-SMA in high grade glioma, particularly at the thick-wall MVs (Fig. 4A,B) and the pericytes around the zone of necrotic or hemorrhagic areas in WHO grade IV glioma(Fig. 4A). The gene discussed is MKI67; the disease is central nervous system cancer.