Seven studies examined seven different risk models with dementia as the outcome including: the Framingham CVD model [22], the CAIDE model (three studies: one study used CAIDE model 1 [11], one study used CAIDE model 2 (with ApoE4 status included) [23] and one study examined both CAIDE models [10]), the vascularity index model [19], the vascular index [24], the atherosclerotic risk profile [25], the hypoperfusion risk profile [25] and a cardiovascular composite model [26]. This evidence concerns the gene APOE and dementia.