TLR4 and leukemia: Recently, we showed that also in ECs and VSMCs cross-talk between IFNγ and TLR4 resulted in augmented STAT1 phosphorylation and increased expression of the chemokine CXCL10 and the adhesion molecule ICAM-1 as well as adhesion of U937 leukemia cells to ECs, in a STAT1- and TLR4-dependent manner [17].