SHBG and prostate carcinoma: Antitumour activity has been shown in a number of studies on U. dioica particularly in prostate growths including antiproliferative properties on human prostate cancer cells [27], inhibition of membrane Na+, K+ ATPase activity in benign prostatic hyperplasia through the steroidal component of U. dioica root [28], and modulation of sex hormone-binding globulin to its receptor on human prostatic membranes [29].