Thus a dermatologist/treating physician and pathologists should be aware of genetic classification of MTC (Table 2) in setting of dermatological metastases or other multicentric metastases in sporadic cases of young as various investigations and tools for genetic screening of patients and their relatives are now available which can identify germ line RET as well as other non-RET mutations. The gene discussed is RET; the disease is medullary thyroid gland carcinoma.