The entire IL-8 region was sequenced to determine the allele architecture of the gene, identifying three AMD-associated SNPs (rs2227346 C/T, rs1126647 A/T, and rs4073 A/T) and one susceptibility haplotype (A-T-T-T, P value = 2.8∗10−9, OR = 1.68, 95% CI = 1.43–1.97). This evidence concerns the gene CXCL8 and age-related macular degeneration.