For example, in the Chinese Han population, increased susceptibility to sepsis is conferred by polymorphisms in the TOLLIP gene that result in reduced TOLLIP function.22 Similarly, functional polymorphisms in a Vietnamese population have been associated with susceptibility to tuberculosis.23 In a Caucasian population, TOLLIP gene polymorphisms have been weakly associated with increased susceptibility to atopic dermatitis.24 Observational data suggest that TOLLIP expression is reduced in tissue from coeliac disease and necrotising enterocolitis.25, 26. Here, TOLLIP is linked to atopic eczema.