TGFB1 and leiomyoma: Consistent with the enhanced TGFβ signaling in the etiology of leiomyoma, a number of substances or drugs, such as genistein [94], relaxin [95], halofuginone [96], asoprisnil [97], gonadotropin-releasing hormone-analogs (GnRH-a), and tibolone [98] may influence leiomyoma development via affecting TGFβ signaling.