In this study, we have analyzed the gene and protein expression profile of DNMT and MBD proteins in two breast cancer cell lines after treatment with various epigenetic drugs such as DNMT and HDAC inhibitors- 5-Aza-2'-deoxycytidine (AZA), Trichostatin A (TSA) and Sulforaphane (SFN), respectively, and modulator SAM. Here, DNMT1 is linked to breast cancer.