A recent study showed that a single nucleotide variant numbered rs145999145 in exon 7 of the human PLD3 gene on chromosome 19q13.2, comprised of p.Val232Met located in the phosphodiesterase domain close to the HKD motif, confers a doubled risk for development of late-onset AD in a large case–control series [5]. The gene discussed is PLD3; the disease is Alzheimer disease.