PLD3 and Alzheimer disease: AT8-positive neurofibrillary tangles in the hippocampal neurons were frequently decorated with PLD3 immunoreactivity (Figure 5d), whereas the vacuoles of granulovacuolar degeneration, which are most often found in the hippocampal CA1 region of AD brains, were devoid of PLD3 immunoreactivity (Figure 6d).