The nonsynonymous single nucleotide polymorphism rs145999145 comprised of p.V232M corresponding to c.694G > A in exon 7 represents the most significant AD risk-associated variant among several single nucleotide polymorphisms on PLD3, on which the M232 isoform confers a doubled risk for development of late-onset AD [5]. The gene discussed is PLD3; the disease is Alzheimer disease.