GRN and infantile neuronal ceroid lipofuscinosis: By searching the genes coexpressed with PLD3 on COXPRESdb [23], we identified the human GRN gene encoding PGRN, whose mutation is responsible for frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis [24], ranked as the second most significant gene coexpressed with PLD3 (Additional file 6).