A possible explanation for increased CSF aSyn levels (in addition to the inverse of the mechanisms described above) might be that they partly reflect neuronal and/or axonal injury, which would be in line with a correlation of total tau values and aSyn in CSF samples of AD patients [71], although a correlation between aSyn levels and regional brain atrophy could not be detected [72]. This evidence concerns the gene MAPT and Alzheimer disease.