MAPT and Alzheimer disease: DC8E8 targets all developmental stages of neurofibrillary lesions in human AD brain tissue, including pretangle stage (Figure 2D), intracellular NFTs (Figure 2E) and extracellular NFTs (Figure 2F).On the molecular level, DC8E8 recognises truncated tau proteins, full-length tau proteins corresponding to monomeric tau forms and assembled tau proteins with higher molecular weights corresponding to oligomeric tau forms in the human brain tissue assessed by Western blot analysis (Figure 2G).