APOE and Alzheimer disease: Finally, with regard to disease severity C3, FH and C3/FH did not associate with baseline ADAS-cog, MMSE, memory summary or executive function summary scores of AD (Table 3) or MCI (Table 4) subjects in mixed-effects models adjusted for age, gender, education, APOE ε4 presence and t-tau/Aβ1–42 ratio.