Although no association was found between the complement proteins and clinical diagnosis or cognitive measures, lower levels of C3 (β = −0.12, p = 0.041) and FH (β = −0.075, p = 0.041) were associated with faster cognitive decline in MCI subjects as measured by the AD Assessment Scale-cognitive subscale (ADAS-Cog) test. This evidence concerns the gene VTN and Mental deterioration.