High mobility group box 1 (HMGB1), a 30 kDa nuclear protein involved in the structural organization of deoxyribonucleic acid (DNA), serves as a mediator of inflammation after being released by necrotic cells or upon cellular activation in various pathological conditions including diverse cardiovascular diseases and myocardial ischemia-reperfusion (I/R) injury [5–8]. Here, HMGB1 is linked to cardiovascular disorder.