IL6 and Cachexia: In the present study, marked increases of serum IL-6 levels and cachexia related body weight decrease, reduce and atrophic changes of deposited periovarian fat pads were observed after H520 cell transplantation, but these cachexia related changes were dramatically inhibited by treatment of all three different dosages of platycodin D, dose-dependently, as compared with tumor-bearing control mice, respectively.