CASP3 and neoplasm: Platycodin D 200, 100 or 50 mg/kg administrated mice showed significant and dose-dependent increases of the tumor mass caspase-3 and PARP immunolabeled cells as compared with tumor-bearing control mice, as direct evidences that administration of platycodin D favorably potentiated the apoptosis of tumor cells, similar to those of gemcitabine.