Similar to previous studies, we also observed pleiotropy for a number of loci in particular PTPN22 for JRA, T1DM, and Thyroiditis, IL5 for Eosinophilia, Asthma, and EoE and NDFIP1 for Mental Retardation traits and Cerebral Palsy. The gene discussed is PTPN22; the disease is type 1 diabetes mellitus.