It is also worth mentioning that miRNAs may act in non-hematopoietic cell-intrinsic manners to promote leukemogenesis, as demonstrated by Raaijmakers et al. (2010), who showed that deleting the miRNA processing enzyme, DICER1, in mouse osteoprogenitors induces MDS which progresses to AML. The gene discussed is DICER1; the disease is acute myeloid leukemia.