It is also worth mentioning that miRNAs may act in non-hematopoietic cell-intrinsic manners to promote leukemogenesis, as demonstrated by Raaijmakers et al. (2010), who showed that deleting the miRNA processing enzyme, DICER1, in mouse osteoprogenitors induces MDS which progresses to AML. This evidence concerns the gene DICER1 and myelodysplastic syndrome.