TRAF6 and leukemia: Concurrent transduction of dominant-negative TRAF6 into mouse HSPCs reversed the phenotype, indicating that IL-6 induction by miR-146a knockdown is mediated through TRAF6. Interestingly, the leukemogenic activity of TRAF6 was not affected when overexpressed in IL-6-null HSPCs, suggesting that a non-IL-6 dependent mechanism mediates the role of TRAF6 in the development of leukemia.