CCNT2 and acute myeloid leukemia: These changes were also accompanied by a reduction in phosphorylated Rb (pRb) due to the miR-29 targeting of CDK6 and CCNT2. Similar findings were generated by Gong et al. (2014), who showed that overexpressing miR-29 family members in AML cell lines stimulates apoptosis and inhibits the G1 to S phase cell cycle transition, phenotypes attributed to the miR-29 targeting of CCND2 and AKT2 (Gong et al., 2014; Figure 3D).