Additional studies are necessary to elucidate the relative contribution of miR-146a to del(5q) MDS pathogenesis by investigating the potential additive or synergistic effects of miR-146a with other genes located in the 5q deleted region (e.g., ribosomal protein RPS14; Ebert et al., 2008) using both mouse models and primary MDS patient samples. This evidence concerns the gene RPS14 and myelodysplastic syndrome.