miR-125b overexpression blocks terminal (monocytic and granulocytic) differentiation in HL60 and NB4 AML cell lines (Bousquet et al., 2008; Klusmann et al., 2010) and confers interleukin-3 (IL-3) growth independence to the leukemic cell line, 32Dclone3 (Bousquet et al., 2012). This evidence concerns the gene IL3 and acute myeloid leukemia.