INS and hypertensive disorder: In fact, SNPs rs4122198, rs2394186, rs1619379, and rs1611133 near the HLA-G gene have been associated with type 1 diabetes (93); dendritic cells from type 1 diabetic patients produce lower HLA-G molecules in response to IFN-beta (94) in comparison with control subjects and the HLA-G 14bp INS-INS genotype might contribute to the development of high blood pressure in type 2 diabetes (95).