A systematic review of 15 MRI and 4 post-mortem studies found evidence for brain structural abnormalities after cannabis use in psychosis in CB1-rich areas of the brain-like cingulum, the dorsolateral prefrontal cortex, and the cerebellum, and the authors suggested that the effect of cannabis is actually more distinct in psychosis than in the normal controls (154). Here, CNR1 is linked to psychotic disorder.