IFNG and Anxiety: In this regard, we previously found that IFN-γ-deficient mice had attenuated hormonal, cytokine and brain regional dopaminergic responses to chronic stress, despite showing several conspicuous behavioral and physiological differences in the basal state (i.e., increased anxiety-like behavior, elevated circulating corticosterone levels and central amygdala monoamine utilization; Litteljohn et al., 2010).